The T cell receptor displays lateral signal propagation involving non-engaged receptors

Author:

Nieves Daniel J.12ORCID,Pandzic Elvis3,Gunasinghe Sachith D.1,Goyette Jesse1ORCID,Owen Dylan M.2,Justin Gooding J.4ORCID,Gaus Katharina1

Affiliation:

1. EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, Sydney, Australia

2. Institute of Immunology and Immunotherapy, School of Mathematics, and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK

3. Katharina Gaus Light Microscopy Facility, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, Australia

4. School of Chemistry and Australian Centre for NanoMedicine, University of New South Wales, Sydney, Australia

Abstract

TCR-CD3 signal propagation is probed by super-resolution microscopy and nano-clustered TCR ligands. TCR-CD3 clusters exceeded the ligand cluster boundaries, requiring multivalent interactions facilitated by TCR-CD3 phosphorylation for assembly.

Funder

National Health and Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3