Structural impact of thioamide incorporation into a β-hairpin

Author:

Fiore Kristen E.1ORCID,Patist Martijn J.1,Giannakoulias Sam1ORCID,Huang Cheng-Hsin2,Verma Hitesh3,Khatri Bhavesh3,Cheng Richard P.2ORCID,Chatterjee Jayanta3ORCID,Petersson E. James1ORCID

Affiliation:

1. Department of Chemistry, University of Pennsylvania, 231 S. 34th Street, Philadelphia, 19104, USA

2. Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan

3. Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India

Abstract

NMR studies of macrocyclic β-hairpin model systems demonstrate that thioamides can be tolerated at both hydrogen bond donor and hydrogen bond acceptor positions.

Funder

Ministry of Science and Technology, Taiwan

Department of Science and Technology, Ministry of Science and Technology, India

National Institutes of Health

National Science Foundation

University of Pennsylvania

Ministry of Human Resource Development

University Grants Commission

Department of Biotechnology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

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