Modular construction of α-furanyl ketones <i>via</i> semi-pinacol rearrangement-mediated ring expansion-Reference-Cited by-同舟云学术

Modular construction of α-furanyl ketones via semi-pinacol rearrangement-mediated ring expansion

Published:2022 Issue:22 Volume:9 Page:6194-6199
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Chen Yang¹,Zhu Shifa¹²^ORCID

Affiliation:

1. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China

2. Guangdong Youmei Institute of Intelligent Biomanufacturing, Foshan 528225, PR China

Abstract

An efficient semi-pinacol rearrangement strategy of enynals involving a metal carbene intermediate has been developed, which allows the practical synthesis of various functionalized α-furanyl ketones in moderate to good yields under mild reaction conditions.

Funder

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO01324J

Reference61 articles.

1. Thromboxane synthetase inhibitors and antihypertensive agents. 1. N-[(1H-imidazol-1-yl)alkyl]aryl amides and N-[(1H-1,2,4-triazol-1-yl)alkyl]aryl amides

2. Palladium-Catalyzed α-Arylation Reactions in Total Synthesis