Synthesis of imidazo[1,2-<i>a</i>]pyridinones <i>via</i> a visible light-photocatalyzed functionalization of alkynes/nitrile insertion/cyclization tandem sequence using micro-flow technology-Reference-Cited by-同舟云学术

Synthesis of imidazo[1,2-a]pyridinones via a visible light-photocatalyzed functionalization of alkynes/nitrile insertion/cyclization tandem sequence using micro-flow technology

Published:2024 Issue:1 Volume:11 Page:83-88
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wei Minghui¹,Chen Jiankun¹,Liu Chengkou¹,Yang Zhao²,Qin Hong¹,Hu Yujing¹,Duan Jindian¹,Li Yuguang³,Fang Zheng¹⁴^ORCID,Guo Kai¹⁴^ORCID

Affiliation:

1. College of Biotechnology and Pharmaceutical Engineering Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, China

2. College of Engineering, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210003, China

3. Institute of Nanjing Advanced Biomaterials & Processing Equipment, China

4. State Key Laboratory of Materials-Oriented Chemical Engineering, 30 Puzhu Rd S., Nanjing, 211816, China

Abstract

We successfully developed an unprecedented route for imidazo[1,2-a]pyridinone synthesis through a visible light-photocatalysed functionalization of alkynes/nitrile insertion/cyclization tandem sequence in a microchannel reactor.

Funder

National Natural Science Foundation of China

Jiangsu National Synergistic Innovation Center for Advanced Materials

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D3QO01508D

Reference39 articles.

1. An Efficient Synthetic Route to New Imidazo[1,2-a]pyridines by Cross-Coupling Reactions in Aqueous Medium

2. Novel Dicationic Imidazo[1,2-a]pyridines and 5,6,7,8-Tetrahydro-imidazo[1,2-a]pyridines as Antiprotozoal Agents

3. Synthesis and Evaluation of 7H-8,9-Dihydropyrano[2,3-c]imidazo[1,2-a]pyridines as Potassium-Competitive Acid Blockers

4. Regiospecific Synthesis of 3-Substituted Imidazo[1,2-a]pyridines, Imidazo[1,2-a]pyrimidines, and Imidazo[1,2-c]pyrimidine

5. Synthesis and biological activity of imidazopyridine anticoccidial agents: Part II