Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen-Reference-Cited by-同舟云学术

Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen

Published:2016 Issue:3 Volume:14 Page:1031-1038
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Alanine T. A.¹²³⁴⁵,Galloway W. R. J. D.¹²³⁴,Bartlett S.¹²³⁴,Ciardiello J. J.¹²³⁴,McGuire T. M.⁵⁶⁴,Spring D. R.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Cambridge

4. UK

5. AstraZeneca UK Ltd.

6. Macclesfield

Abstract

Pyrido[1,2-a]pyrimidin-2-ones and related azabicycles with a ring-junction nitrogen represent attractive structural templates for drug discovery.

Funder

Wellcome Trust

Medical Research Council

Engineering and Physical Sciences Research Council

AstraZeneca

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB01784J

Reference27 articles.

1. Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation

2. Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis

3. J. J. Lie , Chapter 1: Introduction, in Heterocyclic Chemistry in Drug Design, ed. J. J. Lie, John Wiley & Sons, Inc, Hoboken, New Jersey, 2013, pp. 1–16

4. Towards the systematic exploration of chemical space

5. Scaffold Diversity of Exemplified Medicinal Chemistry Space

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