Heparin-based hydrogel scaffolding alters the transcriptomic profile and increases the chemoresistance of MDA-MB-231 triple-negative breast cancer cells-Reference-Cited by-同舟云学术

Heparin-based hydrogel scaffolding alters the transcriptomic profile and increases the chemoresistance of MDA-MB-231 triple-negative breast cancer cells

Published:2020 Issue:10 Volume:8 Page:2786-2796
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Menon Nidhi¹²³⁴⁵^ORCID,Dang Ha X.⁶⁷⁴⁸⁹,Datla Udaya Sree¹²³⁴⁵^ORCID,Moarefian Maryam¹⁰³¹¹⁴,Lawrence Christopher B.⁵³¹¹⁴,Maher Christopher A.⁶⁷⁴⁸⁹,Jones Caroline N.¹²³⁴⁵^ORCID

Affiliation:

1. Graduate Program in Translational Biology

2. Medicine and Health

3. Virginia Polytechnic Institute and State University

4. USA

5. Department of Biological Sciences

6. McDonnell Genome Institute

7. Washington University in St. Louis

8. Department of Medicine

9. Washington University School of Medicine

10. Department of Mechanical Engineering

11. Blacksburg

Abstract

The solid-phase presentation of growth factors in heparin-based hydrogel alters the transcriptomic profile and increases the chemoresistance of MDA-MB-231 cells.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/BM/C9BM01481K

Reference59 articles.

1. Heralding a new paradigm in 3D tumor modeling

2. The tumor microenvironment and its role in promoting tumor growth

3. Targeting the tumour stroma to improve cancer therapy