Synthesis, nanostructuring and in silico studies of a new imine bond containing a macroheterocycle as a promising PBP-2a non-β-lactam inhibitor

Author:

Huseynzada Alakbar1234ORCID,Aghayev Mirjavid5ORCID,Hajiyeva Sarvinaz16ORCID,Israyilova Aygun7284ORCID,Sayin Koray9,Gasimov Eldar10ORCID,Rzayev Fuad11ORCID,Hasanova Ulviyya124,Eyvazova Goncha12,Abbasov Vagif13,Gakhramanova Zarema2,Huseynova Sanam14,Huseynova Parvana15,Huseynova Lala16,Salimova Nigar17

Affiliation:

1. ICRL, Baku State University, Z. Khalilov 23, Baku, AZ 1148, Azerbaijan

2. GPOGC SRI, Azerbaijan State Oil and Industry University, Baku, AZ 1010, Azerbaijan

3. Chemistry Department, Azerbaijan Engineers Union, Bashir Safaroglu 118, Baku, AZ 1009, Azerbaijan

4. ICESCO Biomedical Materials Department, Baku State University, Z. Khalilov 23, Baku, AZ 1148, Azerbaijan

5. Department of Pharmaceutical Sciences, Northeast Ohio Medical University, 4209 St, OH-44, Rootstown, OH 44272, USA

6. Physics Department, Kent State University, 800 E. Summit St., Kent, OH 44242, USA

7. Laboratory of Microbiology and Virology, Baku State University, Z. Khalilov 23, Baku, AZ 1148, Azerbaijan

8. Research Institute of Crop Husbandry, Ministry of Agriculture, Baku, AZ 1098, Azerbaijan

9. Chemistry Department, Faculty of Science, Sivas Cumhuriyet University, Sivas, 58140, Turkey

10. Department of Cytology, Embryology and Histology, Azerbaijan Medical University, 163 A Samad Vurgun, Baku AZ1078, Azerbaijan

11. Laboratory of Electron Microscopy of the SRC, Azerbaijan Medical University, 163 A Samad Vurgun, Baku AZ1078, Azerbaijan

12. Nanoresearch Center, Baku State University, Z. Khalilov 23, Baku, AZ 1148, Azerbaijan

13. Institute of Petrochemical Processes, K. Avenue 30, Baku, AZ 1005, Azerbaijan

14. Department of Molecular Biology and Biotechnology, Baku State University, Z. Khalilov 23, Baku, AZ 1148, Azerbaijan

15. Chemistry Department, Ganja State University, H. Aliyev 429, Ganja, AZ 2001, Azerbaijan

16. Industrial Safety and Labor Protection Department, Azerbaijan State Oil and Industry University, Baku, AZ 1010, Azerbaijan

17. Petrochemical Technology and Industrial Ecology Department, Azerbaijan State Oil and Industry University, Baku, AZ 1010, Azerbaijan

Abstract

This study describes the synthesis of a 40-membered macroheterocycle, promising PBP-2a non-β-lactam. The MIC of MHC3@Fe3O4 towards S. aureus is ≤0.5 μg mL−1 and in silico studies showed the high affinity of MHC3 to the allosteric site of PBP-2a.

Funder

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu

Elmin Inkişafı Fondu

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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