Catalytic asymmetric synthesis of CF3-substituted tertiary propargylic alcohols via direct aldol reaction of α-N3amide-Reference-Cited by-同舟云学术

Catalytic asymmetric synthesis of CF3-substituted tertiary propargylic alcohols via direct aldol reaction of α-N3amide

Published:2017 Issue:4 Volume:8 Page:3260-3269
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Noda Hidetoshi¹²³^ORCID,Amemiya Fuyuki¹²³,Weidner Karin¹²³,Kumagai Naoya¹²³^ORCID,Shibasaki Masakatsu¹²³^ORCID

Affiliation:

1. Institute of Microbial Chemistry (BIKAKEN)

2. Tokyo 141-0021

3. Japan

Abstract

The catalyst comprising Cu(ii)/chiral hydroxamic acid was found to play a bifunctional role in the direct aldol reaction of α-N₃amide to alkynyl CF₃ketones.

Funder

Japan Society for the Promotion of Science

Japan Science and Technology Agency

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC00330G

Reference117 articles.

1. P. Kirsch , Modern Fluoroorganic Chemistry: Synthesis, Reactivity, Applications, Wiley-VCH: Weinheim, Germany, 2004

2. Fluorine in Pharmaceuticals: Looking Beyond Intuition

3. Understanding organofluorine chemistry. An introduction to the C–F bond

4. Fluorine in medicinal chemistry

5. The influence of fluorine in asymmetric catalysis

Cited by 69 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Lewis Acid‐Catalyzed Tandem Annulation of Propargylic Alcohols with 2‐Allylphenols and Their Anti‐tumor Activities;Asian Journal of Organic Chemistry;2024-08-19

2. Diastereoselective Aldol Reaction of α‐Azido Ketones with α‐CF₃ Pyruvate to Organoazides with Vicinal Tetrasubstituted Carbons;European Journal of Organic Chemistry;2024-06-17

3. Organocatalytic Stereoselective Decarboxylative Addition of α‐Amido Malonic Acid Half Oxyesters to Isatins;Advanced Synthesis & Catalysis;2024-01-16

4. Pd((R)-DTBM-SEGphos)Cl₂-catalyzed kinetic resolution of tertiary propargylic alcohols;Organic Chemistry Frontiers;2024

5. The Aldol Reaction: Transition Metal Enolates;Reference Module in Chemistry, Molecular Sciences and Chemical Engineering;2024