Analysis of terbinafine in PLGA-based drug delivery systems by a fast and sensitive UHPLC-DAD method

Author:

Mrštná Kristýna12ORCID,Matoušová Kateřina2ORCID,Matouš Petr3ORCID,Matysová Ludmila1,Švec František1,Šnejdrová Eva4,Krčmová Lenka Kujovská12ORCID

Affiliation:

1. The Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203/8, 50005 Hradec Králové, Czech Republic

2. The Department of Clinical Biochemistry and Diagnostics, University Hospital Hradec Králové, Sokolská 581, 50005 Hradec Králové, Czech Republic

3. The Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 50005 Hradec Králové, Czech Republic

4. The Department of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 50005 Hradec Králové, Czech Republic

Abstract

An ultra-high performance chromatography method with multichannel detection for fast, sensitive, and robust analysis of terbinafine and its three impurities β-terbinafine, (Z)-terbinafine, and 4-methylterbinafine in just 5.0 min has been developed.

Funder

Fakultní nemocnice Hradec Králové

European Regional Development Fund

Univerzita Karlova v Praze

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

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