A new graphene-based nanomaterial increases lipolysis and reduces body weight gain through integrin linked kinase (ILK)-Reference-Cited by-同舟云学术

A new graphene-based nanomaterial increases lipolysis and reduces body weight gain through integrin linked kinase (ILK)

Published:2023 Issue:14 Volume:11 Page:4916-4929
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

de Frutos Sergio¹²^ORCID,Griera Mercedes³,Lavín-López Maria del Prado⁴^ORCID,Martínez-Rovira Martín⁴,Martínez-Rovira José António⁴,Rodríguez-Puyol Manuel¹²,Rodríguez-Puyol Diego⁵²

Affiliation:

1. Department of Systems Biology of Universidad de Alcalá (UAH), 28805 Alcalá de Henares, Madrid, Spain

2. Instituto Ramon y Cajal de Investigación Sanitaria (IRYCIS), Fundación Renal Iñigo Álvarez de Toledo (FRIAT), RICOR from Instituto de Salud Carlos III and NOVELREN from Comunidad de Madrid, Spain

3. Graphenano Medical Care S.L., Madrid, Spain

4. Graphenano S.L., Murcia, Spain

5. Department of Medicine of Universidad de Alcalá (UAH), Nephrology Department at Hospital Príncipe de Asturias, Instituto Ramon y Cajal de Investigación Sanitaria (IRYCIS), Fundación Renal Iñigo Álvarez de Toledo (FRIAT), RICOR from Instituto de Salud Carlos III and NOVELREN from Comunidad de Madrid, Spain

Abstract

Graphene-based GMC binds to integrinβ1/ILK cluster to reduce adipocyte triglyceride storage in hypertrophied subcutaneous adipose tissue and increases, in turn, ILK expression and lipolysis.

Funder

Instituto de Salud Carlos III

Comunidad de Madrid

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D2BM01791A

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