Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries-Reference-Cited by-同舟云学术

Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries

Published:2021 Issue:27 Volume:12 Page:9475-9484
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hunter James H.¹²³⁴⁵,Anderson Matthew J.¹²³⁴⁵,Castan Isaline F. S. F.¹²³⁴⁵,Graham Jessica S.¹²³⁴⁵,Salvini Catherine L. A.¹²³⁴⁵,Stanway-Gordon Harriet A.¹²³⁴⁵,Crawford James J.⁶⁷⁸⁹^ORCID,Madin Andrew¹⁰¹¹¹²¹³¹⁴,Pairaudeau Garry¹⁵¹⁶¹⁷,Waring Michael J.¹²³⁴⁵

Affiliation:

1. Cancer Research UK Newcastle Drug Discovery Unit

2. Chemistry

3. School of Natural and Environmental Sciences

4. Newcastle University

5. Newcastle upon Tyne

6. Department of Discovery Chemistry

7. Genentech Inc.

8. South San Francisco

9. USA

10. Hit Discovery

11. Discovery Sciences

12. R&D

13. AstraZeneca

14. Cambridge

15. Exscientia

16. Oxford

17. UK

Abstract

Highly efficient forward and reverse on-DNA amide couplings were developed exploiting hydrophobic linkers in combination with the micelle forming surfactant TPGS-750M. The method is highly effective for a wide range of substrates in the synthesis of DNA-encoded libraries.

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

Genentech

Cancer Research UK

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC03007H