Graphene oxide activates B cells with upregulation of granzyme B expression: evidence at the single-cell level for its immune-modulatory properties and anticancer activity-Reference-Cited by-同舟云学术

Graphene oxide activates B cells with upregulation of granzyme B expression: evidence at the single-cell level for its immune-modulatory properties and anticancer activity

Published:2022 Issue:2 Volume:14 Page:333-349
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Orecchioni Marco¹,Fusco Laura²³⁴^ORCID,Mall Raghvendra⁵^ORCID,Bordoni Valentina¹,Fuoco Claudia⁶,Rinchai Darawan²,Guo Shi⁷,Sainz Raquel⁷,Zoccheddu Martina¹,Gurcan Cansu⁸,Yilmazer Acelya⁸^ORCID,Zavan Barbara⁹,Ménard-Moyon Cécilia⁷^ORCID,Bianco Alberto⁷^ORCID,Hendrickx Wouter²¹⁰,Bedognetti Davide²¹⁰¹¹,Delogu Lucia Gemma¹³^ORCID

Affiliation:

1. Department of Chemistry and Pharmacy University of Sassari, Sassari, Italy

2. Department of Immunology, Cancer Program, Sidra Medicine, Education City, Doha, Qatar

3. Department of Biomedical Sciences, University of Padua, Padua, Italy

4. Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy

5. Qatar Computing Research Institute (QCRI) Hamad Bin Khalifa University (HBKU), Doha, Qatar

6. Department of Biology, University of Rome Tor Vergata, Rome, Italy

7. CNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University of Strasbourg, ISIS, 67000 Strasbourg, France

8. Department of Biomedical Engineering, Faculty of Engineering, Ankara University, Ankara, Turkey

9. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

10. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar

11. Dipartimento di Medicina Interna e Specialità Mediche, Università degli Studi di Genova, Genova, Italy

Abstract

While both graphene oxide and amino functionalized graphene oxide exert strong pro-activating properties on B cells, the latter is also able to induce a B cell receptor signaling dysregulation, which triggers the production of granzyme B.

Funder

Horizon 2020 Framework Programme

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D1NR04355B

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1. Graphene gets ready for the big time

2. The rise of graphene