Direct arylation of alkyl fluorides using <i>in situ</i> mechanochemically generated calcium-based heavy Grignard reagents-Reference-Cited by-同舟云学术

Direct arylation of alkyl fluorides using in situ mechanochemically generated calcium-based heavy Grignard reagents

Published:2024 Issue: Volume: Page:
ISSN:2976-8683
Container-title:RSC Mechanochemistry
language:en
Short-container-title:RSC Mechanochem.

Author:

Gao Pan¹,Jiang Julong²,Fukuzawa Yamato¹,Maeda Satoshi²³^ORCID,Kubota Koji¹³^ORCID,Ito Hajime¹³^ORCID

Affiliation:

1. Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido, Japan

2. Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, Hokkaido, Japan

3. Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo, Hokkaido, Japan

Abstract

Here, we report the reaction of calcium-based heavy Grignard reagents, which are easily generated by a mechanochemical method, with unactivated alkyl fluorides to produce the arylated products in moderate to good yields.

Funder

Japan Society for the Promotion of Science

Japan Science and Technology Corporation

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MR/D4MR00067F

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