Honey protects against cisplatin-induced hepatic and renal toxicity through inhibition of NF-κB-mediated COX-2 expression and the oxidative stress dependent BAX/Bcl-2/caspase-3 apoptotic pathway-Reference-Cited by-同舟云学术

Honey protects against cisplatin-induced hepatic and renal toxicity through inhibition of NF-κB-mediated COX-2 expression and the oxidative stress dependent BAX/Bcl-2/caspase-3 apoptotic pathway

Published:2018 Issue:7 Volume:9 Page:3743-3754
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Neamatallah Thikryat¹²³⁴⁵,El-Shitany Nagla A.¹²³⁴⁵^ORCID,Abbas Aymn T.⁶⁷³⁴⁵,Ali Soad S.⁸⁹¹⁰³⁴,Eid Basma G.¹²³⁴⁵

Affiliation:

1. Department of Pharmacology and Toxicology

2. Faculty of Pharmacy

3. King Abdulaziz University

4. Jeddah

5. Saudi Arabia

6. Special Infectious Agents Unit

7. King Fahd Medical Research Center

8. Anatomy Department of Cytology and Histology

9. and Yousef Abdulatif Jameel Chair of Prophetic Medicine Application

10. Faculty of Medicine

Abstract

The protective effects of both manuka and talh honeys were assessed using a rat model of cisplatin (CISP)-induced hepatotoxicity and nephrotoxicity.

Funder

King Abdulaziz University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2018/FO/C8FO00653A

Reference58 articles.

1. Resveratrol attenuates cisplatin renal cortical cytotoxicity by modifying oxidative stress

2. Cisplatin Preferentially Binds Mitochondrial DNA and Voltage-Dependent Anion Channel Protein in the Mitochondrial Membrane of Head and Neck Squamous Cell Carcinoma: Possible Role in Apoptosis

3. Mechanism of Cisplatin Ototoxicity: Antioxidant System

4. Lipopolysaccharide-induced platinum accumulation in the cerebral cortex after cisplatin administration in mice: Involvement of free radicals

5. Cisplatin-Induced Acute Renal Failure Is Associated with an Increase in the Cytokines Interleukin (IL)-1β, IL-18, IL-6, and Neutrophil Infiltration in the Kidney

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