Synthesis, characterisation and biological evaluation of monometallic Re(i) and heterobimetallic Re(i)/Fe(ii) complexes with a 1,2,3-triazolyl pyridine chelating moiety

Author:

Jakopec Silvio1ORCID,Gourdon-Grünewaldt Lisa2ORCID,Čipor Ivona3ORCID,Meščić Macan Andrijana1ORCID,Perić Berislav4ORCID,Piantanida Ivo3ORCID,Cariou Kevin2ORCID,Gasser Gilles2ORCID,Kirin Srećko I.4ORCID,Raić-Malić Silvana1ORCID

Affiliation:

1. University of Zagreb, Faculty of Chemical Engineering and Technology, Department of Organic Chemistry, Marulićev trg 20, 10 000 Zagreb, Croatia

2. Chimie ParisTech, PSL University, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, France

3. Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Laboratory for Biomolecular Interactions and Spectroscopy, Bijenička cesta 54, 10 000 Zagreb, Croatia

4. Ruđer Bošković Institute, Division of Materials Chemistry, Laboratory for Solid State and Complex Compounds Chemistry, Bijenička cesta 54, 10 000 Zagreb, Croatia

Abstract

Heterobimetallic Re(i) ferrocene dipyridylamine complexes showed antiproliferative effects comparable to cisplatin on colon cancer cells, whereas the Re(i) benzimidazo[1,2-a]quinoline complex accumulated in lysosomes and interacted with biomolecules.

Funder

École Normale Supérieure

H2020 European Research Council

Agence Nationale de la Recherche

European Regional Development Fund

Cogito Foundation

Hrvatska Zaklada za Znanost

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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