A quantum chemical study on the anti-SARS-CoV-2 activity of TMPRSS2 inhibitors-Reference-Cited by-同舟云学术

A quantum chemical study on the anti-SARS-CoV-2 activity of TMPRSS2 inhibitors

Published:2023 Issue:30 Volume:25 Page:20597-20605
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Kondo Akihiro¹,Fujimoto Kazuhiro J.¹²^ORCID,Yanai Takeshi¹²^ORCID

Affiliation:

1. Department of Chemistry, Graduate School of Science, Nagoya University, Furocho, Chikusa, Nagoya, 464-8601, Japan

2. Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Japan

Abstract

Nafamostat and camostat are known to inhibit the spike protein-mediated fusion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by forming a covalent bond with the human transmembrane serine protease 2 (TMPRSS2) enzyme.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CP/D3CP01723K

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