Formation kinetics and physicochemical properties of mesoscopic Alpha-Synuclein assemblies modulated by sodium chloride and a distinct pulsed electric field-Reference-Cited by-同舟云学术

Formation kinetics and physicochemical properties of mesoscopic Alpha-Synuclein assemblies modulated by sodium chloride and a distinct pulsed electric field

Published:2023 Issue:7 Volume:19 Page:1363-1372
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Wang Mengying¹^ORCID,Thuenauer Roland²³⁴^ORCID,Schubert Robin⁵^ORCID,Gevorgyan Susanna¹,Lorenzen Kristina⁵,Brognaro Hévila¹,Betzel Christian¹

Affiliation:

1. University of Hamburg, Laboratory for Structural Biology of Infection and Inflammation, Institute of Biochemistry and Molecular Biology, Notkestrasse 85, c/o DESY, Building 22a, 22607, Hamburg, Germany

2. Technology Platform Light Microscopy, University of Hamburg, Mittelweg 177, 20148, Hamburg, Germany

3. Center for Structural Systems Biology (CSSB), Notkestrasse 85, c/o DESY, Building 15, 22607, Hamburg, Germany

4. Technology Platform Microscopy and Image Analysis (TP MIA), Leibniz Institute of Virology (LIV), Martinistrasse 52, 20251, Hamburg, Germany

5. European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany

Abstract

Pulsed electric fields (EFs) and a NaCl gradient induce the formation of ordered mesoscopic Alpha-Synuclein (ASN) assemblies with red-shifted emission wavelengths and thermostability.

Funder

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SM/D2SM01615J

Reference40 articles.

1. α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling

2. α-Synuclein Has a High Affinity for Packing Defects in a Bilayer Membrane

3. Synapsin I Senses Membrane Curvature by an Amphipathic Lipid Packing Sensor Motif

4. The Function of α-Synuclein

5. Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force

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