Synthesis of trifluoromethyl <i>N</i>,<i>N</i>-aminals from nitrogen containing heterocycles by using a plasma flow microreactor-Reference-Cited by-同舟云学术

Synthesis of trifluoromethyl N,N-aminals from nitrogen containing heterocycles by using a plasma flow microreactor

Published:2023 Issue:28 Volume:59 Page:4213-4216
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Abedelnour Elias¹²^ORCID,Ognier Stephanie¹,Venier Olivier²,Schio Laurent²,Tatoulian Michael¹,Cossy Janine³^ORCID

Affiliation:

1. Chimie ParisTech, PSL University Paris, CNRS, Institut de Recherche de Chimie Paris, UMR8247, 11 rue Pierre et Marie Curie, 75005 Paris, France

2. Sanofi, Integrated Drug Discovery – IDD France, 1 Avenue Pierre Brossolette, Chilly Mazarin, France

3. Molecular, Macromolecular Chemistry and Materials (C3M), ESPCI Paris, PSL University, CNRS, 75005 Paris, France

Abstract

Trifluoromethyl N,N-aminals were synthesized from nitrogen containing heterocycles in a R3SiCF3 solution, using an argon plasma in a flow microreactor. The transformation of the trifluoromethyl N,N-aminals to N-trifluoroethylamine is also reported.

Funder

Institut Pierre-Gilles de Gennes

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC00942D

Reference31 articles.

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2. Enantioselective Synthesis and Physicochemical Properties of Libraries of 3-Amino- and 3-Amidofluoropiperidines

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5. Diastereospecific fluorination of substituted azepanes

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