STAT3/IL-6 dependent induction of inflammatory response in osteoblast and osteoclast formation in nanoscale wear particle-induced aseptic prosthesis loosening-Reference-Cited by-同舟云学术

STAT3/IL-6 dependent induction of inflammatory response in osteoblast and osteoclast formation in nanoscale wear particle-induced aseptic prosthesis loosening

Published:2021 Issue:4 Volume:9 Page:1291-1300
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Deng Zhantao¹²³⁴⁵,Zhang Ruiying¹²³⁴⁵,Li Mengyuan¹²³⁴⁵,Wang Shuai¹²³⁴⁵,Fu Guangtao¹²³⁴⁵,Jin Jiewen⁶⁷⁸⁴⁵,Wang Zhenheng¹⁹¹⁰⁵,Ma Yuanchen¹²³⁴⁵,Zheng Qiujian¹²³⁴⁵^ORCID

Affiliation:

1. Department of Orthopedics

2. Guangdong Provincial People's Hospital

3. Guangdong Academy of Medical Sciences

4. Guangzhou

5. China

6. Department of Endocrinology

7. The First Affiliated Hospital

8. Sun Yat-Sen University

9. The First Affiliated Hospital of Soochow University

10. Soochow

Abstract

Our study demonstrated wear particles, which are generated by the abrasion of implanted prostheses, could induced STAT3 activation in osteoblasts. And further, inflammatory responses and RANKL expression would activate osteoclasts and cause osteolysis.

Funder

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Medical Science and Technology Foundation of Guangdong Province

Guangzhou Municipal Science and Technology Project

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D0BM01256D