Small molecules targeting the NEDD8·NAE protein–protein interaction-Reference-Cited by-同舟云学术

Small molecules targeting the NEDD8·NAE protein–protein interaction

Published:2021 Issue:4 Volume:12 Page:1535-1543
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Lin Chen-Ming¹²³⁴^ORCID,Jiang Zhengyang¹²³⁴,Gao Zhe¹²³⁴,Arancillo Maritess¹²³⁴^ORCID,Burgess Kevin¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Texas A & M University

3. College Station

4. USA

Abstract

Discovery of the first NEDDylation inhibitor, that targets the NEDD8·NAE protein–protein interaction, was acheived using the Exploring Key Orientations (EKO) approach.

Funder

National Institutes of Health

U.S. Department of Defense

Cancer Prevention and Research Institute of Texas

National Science Foundation

Welch Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC00958J

Reference56 articles.

1. Small-Molecule Modulation of Protein Homeostasis

2. Proteasome Inhibitors in Cancer Therapy: Lessons from the First Decade

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5. NEDD8 Pathways in Cancer, Sine Quibus Non

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