Synthesis of difluoromethylated spiropyrazolones <i>via</i> [3 + 2] cycloaddition of difluoroacetohydrazonoyl bromides with alkylidene pyrazolones-Reference-Cited by-同舟云学术

Synthesis of difluoromethylated spiropyrazolones via [3 + 2] cycloaddition of difluoroacetohydrazonoyl bromides with alkylidene pyrazolones

Published:2024 Issue:14 Volume:22 Page:2797-2812
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Feng Yang¹,Ren Yuanyuan¹,Tang Duoduo¹,Wang Ke-Hu¹,Wang Junjiao¹,Huang Danfeng¹,Lv Xiaobo²,Hu Yulai¹³^ORCID

Affiliation:

1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, P. R. China

2. Shanghai Sinofluoro Chemicals Co., Ltd., Shanghai 201321, P. R. China

3. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China

Abstract

Highly functionalized fluoroalkyl spiropyrazolones are synthesized via an effective [3 + 2] cycloaddition of di/trifluoromethyl hydrazonoyl bromides and alkylidene pyrazolones in good yields.

Funder

Lanzhou University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00044G

Reference34 articles.

1. Spirocyclic Scaffolds in Medicinal Chemistry

2. Natural spirocyclic alkaloids and polyphenols as multi target dementia leads

3. Spirocyclic Motifs in Natural Products

4. Spirocyclic derivatives as antioxidants: a review

5. Three-Component Access to Functionalized Spiropyrrolidine Heterocyclic Scaffolds and Their Cholinesterase Inhibitory Activity

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