Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease
Author:
Affiliation:
1. LCC (Laboratoire de Chimie de Coordination)
2. CNRS UPR 8241
3. 31062 Toulouse Cedex 09
4. France
5. Université de Toulouse
6. Observatoire des Sciences de l’Univers de Grenoble (OSUG)
7. CNRS UMS 832
8. 38400 Saint Martin d’Hères
9. BM30B/FAME
Abstract
ROS production proceeds through a Cu–Aβ state in which Cu(i/ii) binds to the NH2 and COO− groups of Asp1 and a histidine.
Funder
H2020 European Research Council
Agence Nationale de la Recherche
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC00809K
Reference80 articles.
1. Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress 1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.
2. Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment
3. Oxidative Stress Hypothesis in Alzheimer's Disease
4. Discussion
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