Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease-Reference-Cited by-同舟云学术

Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease

Published:2017 Issue:7 Volume:8 Page:5107-5118
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Cheignon Clémence¹²³⁴⁵,Jones Megan¹²³⁴⁵,Atrián-Blasco Elena¹²³⁴⁵^ORCID,Kieffer Isabelle⁶⁷⁸⁴⁹,Faller Peter¹²³⁴⁵,Collin Fabrice¹²³⁴⁵,Hureau Christelle¹²³⁴⁵^ORCID

Affiliation:

1. LCC (Laboratoire de Chimie de Coordination)

2. CNRS UPR 8241

3. 31062 Toulouse Cedex 09

4. France

5. Université de Toulouse

6. Observatoire des Sciences de l’Univers de Grenoble (OSUG)

7. CNRS UMS 832

8. 38400 Saint Martin d’Hères

9. BM30B/FAME

Abstract

ROS production proceeds through a Cu–Aβ state in which Cu(i/ii) binds to the NH₂ and COO⁻ groups of Asp1 and a histidine.

Funder

H2020 European Research Council

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC00809K

Reference80 articles.

1. Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress 1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

2. Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

3. Oxidative Stress Hypothesis in Alzheimer's Disease

4. Discussion

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