Dynamic supramolecular self-assembly of platinum(ii) complexes perturbs an autophagy–lysosomal system and triggers cancer cell death-Reference-Cited by-同舟云学术

Dynamic supramolecular self-assembly of platinum(ii) complexes perturbs an autophagy–lysosomal system and triggers cancer cell death

Published:2021 Issue:46 Volume:12 Page:15229-15238
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tong Ka-Chung¹²,Wan Pui-Ki¹²,Lok Chun-Nam¹²^ORCID,Che Chi-Ming¹²^ORCID

Affiliation:

1. State Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China

2. Laboratory for Synthetic Chemistry and Chemical Biology Limited, Units 1503-1511, 15/F., Building 17W, Hong Kong Science Park, New Territories, Hong Kong, China

Abstract

Self-assembly of platinum(ii) glycosylated arylacetylide gave transformable superstructures upon enzymatic action in cellulo, leading to perturbation of an autophagy-lysosomal system and cancer cell death.

Funder

Innovation and Technology Fund

Innovation and Technology Commission - Hong Kong

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02841C

Reference47 articles.

1. Metallointercalation Reagents. 2-Hydroxyethanethiolato(2,2',2''-terpyridine)-platinum(II) Monocation Binds Strongly to DNA By Intercalation

2. Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound