Selective photoregulation of the activity of glycogen synthase and glycogen phosphorylase, two key enzymes in glycogen metabolism-Reference-Cited by-同舟云学术

Selective photoregulation of the activity of glycogen synthase and glycogen phosphorylase, two key enzymes in glycogen metabolism

Published:2015 Issue:26 Volume:13 Page:7282-7288
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Díaz-Lobo Mireia¹²³⁴⁵,Garcia-Amorós Jaume⁶⁷⁸²³,Fita Ignacio⁹³⁴,Velasco Dolores⁶⁷⁸²³,Guinovart Joan J.¹²³⁴⁵,Ferrer Joan C.¹²³⁴

Affiliation:

1. Departament de Bioquímica i Biologia Molecular

2. Universitat de Barcelona

3. Barcelona

4. Spain

5. Institute for Research in Biomedicine (IRB Barcelona)

6. Grup de Materials Orgànics

7. Institut de Nanociència i Nanotecnologia (IN2UB)

8. Departament de Química Orgànica

9. Institut de Biologia Molecular de Barcelona (IBMB-CSIC)

Abstract

An azobenzene glucoside was synthesized and was shown to be an excellent selective inhibitor of Escherichia coli glycogen synthase in its photogenerated (Z)-form, which structurally resembles the three terminal glucoses of a glycogen branch.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00796H

Reference44 articles.

1. Design, Synthesis, and DNA Binding Properties of Photoisomerizable Azobenzene−Distamycin Conjugates: An Experimental and Computational Study

2. Robust and Photocontrollable DNA Capsules Using Azobenzenes

3. Using an Azobenzene Cross-Linker to Either Increase or Decrease Peptide Helix Content upon Trans-to-Cis Photoisomerization

4. Optical control of metabotropic glutamate receptors

5. Photocontrol of Triple-Helix Formation by Using Azobenzene-Bearing Oligo(thymidine)

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