Simple Gd3+-Neu5NAc complexation results in NMR chemical shift asymmetries of structurally equivalent complex-type N-glycan branches

Author:

Usachev Konstantin12345ORCID,Yamaguchi Yoshiki678910ORCID,Takamatsu Masayuki1191012,Pavlova Nataliya12345,Klochkov Vladimir12345,Kurbangalieva Almira1314345ORCID,Murase Takefumi1591012,Shimoda Taiji1591012,Tanaka Katsunori119101213ORCID

Affiliation:

1. NMR Laboratory

2. Institute of Physics

3. Kazan Federal University

4. Kazan 420008

5. Russia

6. Structural Glycobiology Team

7. Systems Glycobiology Research Group

8. RIKEN Global Research Cluster

9. RIKEN

10. Saitama 351-0198

11. Biofunctional Synthetic Chemistry Laboratory

12. Japan

13. Biofunctional Chemistry Laboratory

14. A. Butlerov Institute of Chemistry

15. GlycoTargeting Research Team

Abstract

A quite simple but overlooked approach for conveniently analyzing, assigning, and extracting sialoglycans using NMR without pre-installing metal chelators.

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference16 articles.

1. Analysis of Glycans, Polysaccharide Functional Properties & Biochemistry of Glycoconjugate Glycans, Carbohydrate-mediated Interactions: Comprehensive Glycoscience, From Chemistry to Systems Biology, ed. J. P. Kamerling, G.-J. Boons, Y. C. Lee, A. Suzuki, N. Taniguchi and A. G. J. Voragen, Elsevier, UK, 2007, vol. II & III

2. Synthesis and medical applications of oligosaccharides

3. Enhancement of therapeutic protein in vivo activities through glycoengineering

4. Glycoinsulins:  Dendritic Sialyloligosaccharide-Displaying Insulins Showing a Prolonged Blood-Sugar-Lowering Activity

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