Rapid and sensitive detection of dual lung cancer-associated miRNA biomarkers by a novel SERS-LFA strip coupling with catalytic hairpin assembly signal amplification

Author:

Cao Xiaowei12345ORCID,Sun Yue67385,Mao Yu67385,Ran Menglin12345,Liu Yifan12345,Lu Dan12345,Bi Caili67385

Affiliation:

1. Department of Obstetrics and Gynecology

2. College of Clinical Medicine

3. Yangzhou University

4. Yangzhou 225009

5. People's Republic of China

6. Institute of Translational Medicine

7. Medical College

8. Yangzhou 225001

Abstract

A novel surface-enhanced Raman scattering-lateral flow assay strip in combination with catalytic hairpin assembly signal amplification has been developed for rapid and sensitive detection of miR-196a-5p and miR-31-5p associated with lung cancer.

Funder

National Natural Science Foundation of China

Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry

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