Immunoactivity of a hybrid membrane biosurface on nanoparticles: enhancing interactions with dendritic cells to augment anti-tumor immune responses

Author:

Yu Luying1,Zhou Ao12,Jia Jingyan1,Wang Jieting1,Ji Xueyang2,Deng Yu1,Lin Xinhua1,Wang Fang2ORCID

Affiliation:

1. Key Laboratory of Nanomedical Technology (Education Department of Fujian Province), Nanomedical Technology Research Institute, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China

2. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China

Abstract

A hybrid membrane biosurface derived from cancer cells and activated macrophages was found to enhance the interaction of nanoparticles with immune cells, which was utilized to develop an anti-tumor nanovaccine loaded with an adjuvant.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Fujian Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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