Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 <i>in vitro</i>-Reference-Cited by-同舟云学术

Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro

Published:2022 Issue:23 Volume:58 Page:3791-3794
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Qiao Zhen¹,Tang Siyuan¹,Guan Jialiang²,Yin Zhengji³,Zhu Chao⁴,Zhou Qiqi⁵,Shao Liming¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China

2. The Department of Emergency Internal Medicine, The Affiliated Hospital of Qingdao University, Shandong 266001, China

3. Departments of Pharmacology, School of Pharmacy, Qingdao University Medical College, #1 Ningde Road, Qingdao 266073, China

4. The Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Shandong 266001, China

5. Department of Pharmacology, Qilu Medical University, Zibo, Shandong 255300, China

Abstract

The first Kv7.2/7.3 fluorescent probes were used to detect and visualize Kv7.2/7.3 channels in cells and mouse brain tissue.

Funder

Natural Science Foundation of Shandong Province

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC00372D

Reference22 articles.

1. KCNQ-Encoded Potassium Channels as Therapeutic Targets

2. Voltage-gated potassium channels as therapeutic targets

3. Pathways modulating neural KCNQ/M (Kv7) potassium channels

4. KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel

5. Validation of an Atomic Absorption Rubidium Ion Efflux Assay for KCNQ/M-Channels Using the Ion Channel Reader 8000

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