How does the mutation in the cap domain of methylcobalamin-dependent methionine synthase influence the photoactivation of the Co

How does the mutation in the cap domain of methylcobalamin-dependent methionine synthase influence the photoactivation of the Co–C bond?

Published:2019 Issue:37 Volume:21 Page:20628-20640
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Ghosh Arghya Pratim¹²³⁴^ORCID,Mamun Abdullah Al¹²³⁴^ORCID,Kozlowski Pawel M.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Louisville

3. Louisville

4. USA

Abstract

The topology of the S₁ PES is modulated by introducing a mutation at the F708 position. The mutation influences the photoactivation of the Co–C bond by decreasing the rate of geminate recombination and altering the rate of radical pair formation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CP/C9CP01849B

Reference63 articles.

1. D. Dolphin , B12 Volume 1: Chemistry , John Wiley & Sons , New York , 1982

2. J. M. Pratt , Inorganic Chemistry of Vitamin B12 , Academic Press , London, New York , 1972

3. R. Banerjee , Chemistry and Biochemistry of B12 , Wiley , New York , 1999

4. Radical Peregrinations Catalyzed by Coenzyme B12-Dependent Enzymes

5. The structure of vitamin B 12 - IV. The X-ray analysis of air-dried crystals of B 12

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Miracle of Vitamin B12 Biochemistry;Reactions;2024-01-05

2. Photolytic properties of B12-dependent enzymes: A theoretical perspective;Vitamins and Hormones;2022

3. Aerobic photolysis of methylcobalamin: unraveling the photoreaction mechanism;Physical Chemistry Chemical Physics;2022

4. Role of the CarH photoreceptor protein environment in the modulation of cobalamin photochemistry;Biophysical Journal;2021-09

5. What Triggers the Cleavage of the Co–C5′ Bond in Coenzyme B12-Dependent Itaconyl-CoA Methylmalonyl-CoA Mutase?;ACS Catalysis;2021-06-16