Benzothiazole DNA gyrase inhibitors and their conjugates with siderophore mimics: design, synthesis and evaluation-Reference-Cited by-同舟云学术

Benzothiazole DNA gyrase inhibitors and their conjugates with siderophore mimics: design, synthesis and evaluation

Published:2024 Issue:5 Volume:14 Page:2905-2917
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Durcik Martina¹,Cruz Cristina D.²,Scorciapino Mariano Andrea³^ORCID,Ilaš Janez¹^ORCID,Tammela Päivi²^ORCID,Ceccarelli Matteo⁴^ORCID,Mašič Lucija Peterlin¹,Tomašič Tihomir¹^ORCID

Affiliation:

1. University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia

2. Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P. O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland

3. Department of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria di Monserrato – S. P. 8 km 0.700, 09042 – Monserrato (CA), Italy

4. Department of Physics and IOM/CNR, Sezione di Cagliari, University of Cagliari, Cittadella Universitaria di Monserrato – S. P. 8 km 0700, 09042 – Monserrato (CA), Italy

Abstract

Potent DNA gyrase and topoisomerase IV inhibitor bearing a siderophore mimic moiety displays improved antibacterial activity against Escherichia coli under iron-depleted conditions.

Funder

Academy of Finland

Javna Agencija za Raziskovalno Dejavnost RS

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA08337C

Reference56 articles.

1. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

2. The Science of Antibiotic Discovery

3. DNA Topoisomerases: Structure, Function, and Mechanism

4. DNA Topoisomerases as Targets for Antibacterial Agents

5. Prospects for Developing New Antibacterials Targeting Bacterial Type IIA Topoisomerases

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