The role of conformational dynamics in the activity of polymer-conjugated CalB in organic solvents-Reference-Cited by-同舟云学术

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The role of conformational dynamics in the activity of polymer-conjugated CalB in organic solvents

Published:2022 Issue:36 Volume:24 Page:22028-22037
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Jian Yupei¹^ORCID,Han Yilei¹,Fu Zhongwang¹^ORCID,Xia Meng¹,Jiang Guoqiang¹,Lu Diannan¹,Wu Jianzhong²^ORCID,Liu Zheng¹³^ORCID

Affiliation:

1. Department of Chemical Engineering, Tsinghua University, Beijing 100084, China

2. Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, USA

3. Jiangsu National Synthetic Innovation Centre for Advanced Materials, Nanjing 211800, China

Abstract

Polymer motion enhances multiscale conformational dynamics, leading to boosted activity of polymer–enzyme conjugates.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP02208G

Reference58 articles.

1. Improving enzymes by using them in organic solvents

2. Why are enzymes less active in organic solvents than in water?

3. Enzyme activation for organic solvents made easy

4. Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding

5. Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.

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