Oxygen self-supplying small size magnetic nanoenzymes for synergistic photodynamic and catalytic therapy of breast cancer

Author:

Cai Xinyi1,Xu Tiantian2,Ding Rui1,Zhang Dou1,Chen Guiquan3,Zhao Wenchang1,Hou Jiajie4,Pan Hong2ORCID,Zhang Qian5,Yin Ting1

Affiliation:

1. Dongguan Key Laboratory of Screening and Research of Anti-inflammatory Ingredients in Chinese Medicine, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China

2. Guangdong Key Laboratory of Nanomedicine, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

3. Department of Gastroenterology, the Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan 523000, China

4. Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China

5. Institute of Nano Biomedicine and Engineering, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai 200240, China

Abstract

In this study, we developed oxygen-supplying magnetic bead nanozymes that integrate hemoglobin and encapsulate the photosensitizer curcumin, demonstrating reactive oxygen species (ROS)-induced synergistic breast cancer therapy.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Traditional Chinese Medicine Bureau of Guangdong Province

Natural Science Foundation of Shanghai

Publisher

Royal Society of Chemistry (RSC)

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