Upgrading furanic platforms to α-enaminones: tunable continuous flow hydrogenation of bio-based cyclopentenones-Reference-Cited by-同舟云学术

Upgrading furanic platforms to α-enaminones: tunable continuous flow hydrogenation of bio-based cyclopentenones

Published:2023 Issue:2 Volume:8 Page:482-489
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Cavaca Lídia A. S.¹^ORCID,Coelho Jaime A. S.²^ORCID,Lucas Susana D.³^ORCID,Loureiro Rui M. S.³,Gomes Rafael F. A.¹^ORCID,Afonso Carlos A. M.¹^ORCID

Affiliation:

1. Research Institute for Medicines (iMed.ULisboa), Faculty of Farmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisbon, Portugal

2. Centro de Química Estrutural, Institute of Molecular Sciences, Faculty of Sciences, Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal

3. Hovione FarmaCiencia SA, Sete Casas, 2674-506 Loures, Portugal

Abstract

Continuous flow hydrogenation of trans-4,5-diamino cyclopentenones to diamino cyclopentanones and base-promoted elimination originates α-enaminones. The strategy is applied to the short synthesis of reported ATP-sensitive potassium channel agonist.

Funder

Fundação para a Ciência e a Tecnologia

H2020 Spreading Excellence and Widening Participation

Federación Española de Enfermedades Raras

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D2RE00292B

Reference41 articles.

1. Recent developments in the chemistry of enaminones