Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease
Author:
Affiliation:
1. Department of Neurology
2. University Medicine Göttingen
3. D-37075 Göttingen, Germany
4. Cluster of Excellence and DFG-Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain
5. Göttingen, Germany
Abstract
The interaction of different metals with the Parkinson's disease-associated protein alpha-synuclein results in oxidative stress, protein aggregation and pathology progression.
Publisher
Oxford University Press (OUP)
Subject
Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2015/MT/C4MT00339J
Reference97 articles.
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4. α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease
5. -Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
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