Pyrazinamide resistance of novel mutations in pncA and their dynamic behavior-Reference-Cited by-同舟云学术

Pyrazinamide resistance of novel mutations in pncA and their dynamic behavior

Published:2020 Issue:58 Volume:10 Page:35565-35573
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ali Arif¹²³⁴⁵,Khan Muhammad Tahir⁶⁷⁸,Khan Abbas¹²³⁴⁵^ORCID,Ali Sajid⁹¹⁰¹¹⁸,Chinnasamy Sathishkumar¹²³⁴⁵,Akhtar Khalid¹²⁸,Shafiq Athar¹²³⁴⁵,Wei Dong-Qing¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Microbial Metabolism

2. School of Life Sciences and Biotechnology

3. and Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences

4. Ministry of Education

5. Shanghai Jiao Tong University

6. Department of Bioinformatics and Biosciences

7. Capital University of Science and Technology

8. Pakistan

9. Quaid-i-Azam University Islamabad

10. Provincial Tuberculosis Reference Laboratory

11. Peshawar

12. National University of Science and Technology

Abstract

We performed several analyses to unveil the pyrazinamide-resistance mechanism of R123P, T76P, G150A, and H71R mutants through molecular dynamics simulations.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People’s Republic of China

Science and Technology Commission of Shanghai Municipality

Shanghai Jiao Tong University

Natural Science Foundation of Henan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA06072K