Density functional theory and liquid chromatography-multistage mass spectrometry to characterize raltitrexed photo-degradation mechanisms-Reference-Cited by-同舟云学术

Density functional theory and liquid chromatography-multistage mass spectrometry to characterize raltitrexed photo-degradation mechanisms

Published:2016 Issue:96 Volume:6 Page:93801-93814
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sadou-Yayé Hassane¹²³⁴⁵,Karoui Maher¹²³⁴⁵,Secrétan Philippe-Henri¹²³⁴⁵,Ghermani Noureddine¹²⁶⁷⁴,Gillet Jean-Michel⁸⁹¹⁰¹¹⁵,Safta Fathi¹²²¹³¹⁴¹⁵,Yagoubi Najet¹²³⁴⁵,Do Bernard¹²³⁴⁵

Affiliation:

1. University of Paris-Sud

2. Department of Pharmacy

3. Laboratory “Matériaux et Santé” EA 401

4. 92296 Châtenay-Malabry

5. France

6. CNRS UMR 8612 Institut Galien Paris-Sud

7. LabEx LERMIT

8. University of Paris-Saclay

9. CNRS UMR 8580

10. Laboratory “Structures Propriétés et Modélisation des Solides” (SPMS)

11. 92295 Châtenay-Malabry

12. University of Monastir

13. Analytical Chemistry Laboratory

14. 5000 Monastir

15. Tunisia

Abstract

The structure of raltitrexed photoproducts was elucidated by LC-ESI-HR-MSⁿ. Photodegradation pathways are proposed, using DFT approach to support assumptions. Ralitrexed photodegrades as per photosensitization mechanisms.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA13144A

Reference34 articles.

1. A systematic review of raltitrexed-based first-line chemotherapy in advanced colorectal cancer

2. Preliminary investigation of intraperitoneal raltitrexed in patients with gastric cancer

3. Hospira Benelux BVBA, AMM BE177825, Noorderplaats 9 2000 Antwerpen, België. Approbation 06/2015

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Electrochemistry Study of Antineoplastic Raltitrexed Oxidation Mechanism and its Interaction with DNA;Electroanalysis;2018-03-14