Biodegradable nanoparticles as siRNA carriers for in vivo gene silencing and pancreatic cancer therapy

Author:

Lin Guimiao12345,Chen Chih-Kuang678910,Yin Feng11121314,Yang Chengbin11121314,Tian Jinglin12345ORCID,Chen Ting12345,Xu Gaixia151617418,He Chunxiao151617418,Lin Marie Chia-Mi12345,Wang Jie12345,Lu Fei192021225,Wang Xiaomei12345,Yong Ken-Tye11121314

Affiliation:

1. Department of Physiology

2. School of Basic Medical Sciences

3. Shenzhen University Health Sciences Center

4. Shenzhen 518060

5. China

6. Department of Fiber & Composite Material

7. Polymer Biomaterial Lab

8. Feng Chia University

9. Taichung 40724

10. Taiwan

11. School of Electrical and Electronic Engineering

12. Nanyang Technological University

13. Singapore 639798

14. Singapore

15. Key Laboratory of Optoelectronics Devices and Systems of Ministry of Education/Guangdong Province

16. College of Optoelectronic Engineering

17. Shenzhen University

18. P. R. China

19. Laboratory of Chemical Genomics

20. School of Chemical Biology & Biotechnology

21. Peking University Shenzhen Graduate School

22. Shenzhen 518055

Abstract

Biodegradable charged polyester-based vectors (BCPVs) were utilized for efficiently delivering mutatedK-Ras-targeting siRNA and successfully inhibiting tumor growth in a pancreatic xenograft modelin vivo.

Funder

Science and Engineering Research Council, Agency for Science, Technology and Research

National Natural Science Foundation of China

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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