Utilization of fluoroform for difluoromethylation in continuous flow: a concise synthesis of α-difluoromethyl-amino acids

Author:

Köckinger Manuel12345,Ciaglia Tanja12345,Bersier Michael6789,Hanselmann Paul6789,Gutmann Bernhard12345ORCID,Kappe C. Oliver12345ORCID

Affiliation:

1. Institute of Chemistry

2. University of Graz

3. NAWI Graz

4. 8010 Graz

5. Austria

6. Microreactor Technology

7. Lonza AG

8. CH-3930 Visp

9. Switzerland

Abstract

Difluoromethylated esters, malonates and amino acids (including the drug eflornithine) are obtained by a gas–liquid continuous flow protocol employing the abundant waste product fluoroform as an atom-efficient reagent.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Reference44 articles.

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2. Organofluorine Compounds in Medicinal Chemistry & Biomedical Applications , ed. R. Filler , Y. Kobayashi and L. M. Yagupolskii , Elsevier , Amsterdam , 1993

3. Difluoromethylation Reactions of Organic Compounds

4. P. Forster , V.Ramaswamy , P.Artaxo , T.Berntsen , R.Betts , D. W.Fahey , J.Haywood , J.Lean , D. C.Lowe , G.Myhre , J.Nganga , R.Prinn , G.Raga , M.Schulz and R.Van Dorland , in Changes in atmospheric constituents and in radiative forcing. In Climate change 2007: The Physical Science Base, Fourth Assessment Report of the Intergovernmental Panel on Climate Change , ed. S. Soloman , D. Qin , M. Manning , Z. Chen , M. Marquis , K. B. Averyt , M. Tignor and H. L. Miller , Cambridge University Press , Cambridge , 2007

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