A facile and efficient strategy to encapsulate the model basic protein lysozyme into porous CaCO3-Reference-Cited by-同舟云学术

A facile and efficient strategy to encapsulate the model basic protein lysozyme into porous CaCO3

Published:2018 Issue:25 Volume:6 Page:4205-4215
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Shi Pengzhong¹²³⁴⁵,Luo Shan¹²³⁴⁵,Voit Brigitte⁶⁷⁸,Appelhans Dietmar⁶⁷⁸^ORCID,Zan Xingjie¹²³⁴⁵^ORCID

Affiliation:

1. School of Ophthalmology and Optometry

2. Eye Hospital

3. School of Biomedical Engineering

4. Wenzhou Medical University

5. Wenzhou

6. Leibniz-Institut für Polymerforschung Dresden e.V.

7. 01069 Dresden

8. Germany

Abstract

A method to load lysozyme, a model of basic protein, with high efficiency and high capacity has been developed by doping heparin into porous CaCO₃ particles. Choosing suitable polyelectrolyte pairs during the layer-by-layer capsule fabrication process avoided losing the loaded lysozyme, and fully retained the bioactivity.

Funder

National Natural Science Foundation of China

Alexander von Humboldt-Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2018/TB/C8TB00312B

Reference54 articles.

1. Enzymes as Drugs

2. Enzyme Therapy: Problems and Solutions