Synthesis and characterization of hyaluronic acid–platinum(iv) nanoconjugate with enhanced antitumor response and reduced adverse effects

Author:

Ling Xiang12345,Zhao Chunyang678910,Huang Liping12345,Wang Qiyue12345,Tu Jiasheng12345,Shen Yan12345,Sun Chunmeng12345

Affiliation:

1. State Key Laboratory of Natural Medicines

2. Department of Pharmaceutics

3. School of Pharmacy

4. China Pharmaceutical University

5. Nanjing 210009

6. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines

7. Institute of Materia Medica

8. Chinese Academy of Medical Sciences & Peking Union Medical College

9. Beijing 100050

10. China

Abstract

HA–EDA–Pt(iv) nanoconjugates were constructed, characterized, and proved as an safe formulation with better blood compatibility and less systemic toxicity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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