Mechanistic investigations of a bifunctional squaramide organocatalyst in asymmetric Michael reaction and observation of stereoselective retro-Michael reaction-Reference-Cited by-同舟云学术

Mechanistic investigations of a bifunctional squaramide organocatalyst in asymmetric Michael reaction and observation of stereoselective retro-Michael reaction

Published:2015 Issue:115 Volume:5 Page:95079-95086
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Varga Eszter¹²³⁴⁵,Mika László Tamás⁶⁷⁸⁴⁵,Csámpai Antal⁹¹⁰⁴⁵,Holczbauer Tamás¹²³⁴⁵,Kardos György¹²³⁴⁵,Soós Tibor¹²³⁴⁵

Affiliation:

1. Institute of Organic Chemistry

2. Research Centre for Natural Sciences

3. Hungarian Academy of Sciences

4. Budapest

5. Hungary

6. Budapest University of Technology and Economics

7. Faculty of Chemical Technology and Biotechnology

8. Department of Chemical and Environmental Process Engineering

9. Institute of Chemistry

10. Eötvös Loránd University

Abstract

The mechanism of cinchona–squaramide organocatalytic Michael addition was studied usingin situIR and NMR experiments. As a result, not only kinetic parameters were determined but a stereoselective retro-Michael reaction was also observed.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA19593D

Reference94 articles.

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3. Recent Advances in Organocatalytic Methods for Asymmetric CC Bond Formation

4. A. Berkessel and H.Gröger, Asymmetric Organocatalysis, Wiley, Weinheim, 2005

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