Acid-catalyzed proton exchange as a novel approach for relaxivity enhancement in Gd-HPDO3A-like complexes-Reference-Cited by-同舟云学术

Acid-catalyzed proton exchange as a novel approach for relaxivity enhancement in Gd-HPDO3A-like complexes

Published:2020 Issue:30 Volume:11 Page:7829-7835
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Leone Loredana¹²³⁴^ORCID,Boccalon Mariangela⁵⁶⁷⁴^ORCID,Ferrauto Giuseppe⁸⁹⁴^ORCID,Fábián István¹⁰¹¹¹²¹³¹⁴^ORCID,Baranyai Zsolt⁵⁶⁷⁴^ORCID,Tei Lorenzo¹²³⁴^ORCID

Affiliation:

1. Department of Science and Technological Innovation

2. Università del Piemonte Orientale

3. Alessandria

4. Italy

5. Bracco Imaging SpA

6. Bracco Research Center

7. Colleretto Giacosa

8. Department of Molecular Biotechnology and Health Science

9. University of Turin

10. Department of Inorganic and Analytical Chemistry

11. MTA-DE Redox and Homogeneous Catalytic Reaction Mechanisms Research Group

12. University of Debrecen

13. H-4032 Debrecen

14. Hungary

Abstract

A novel GdHPDO3A-like complex featuring primary amide side chain induces extraordinary high relaxivity by virtue of a simultaneous double-site proton exchange mechanism under slight acidic conditions.

Funder

Università degli Studi del Piemonte Orientale

Nemzeti Kutatási Fejlesztési és Innovációs Hivatal

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC02174A

Reference37 articles.

1. Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers

2. Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents