<i>In vivo</i> visualization of enantioselective targeting of amyloid and improvement of cognitive function by clickable chiral metallohelices-Reference-Cited by-同舟云学术

In vivo visualization of enantioselective targeting of amyloid and improvement of cognitive function by clickable chiral metallohelices

Published:2023 Issue:3 Volume:14 Page:506-513
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Du Zhi¹,Liu Chun¹²,Liu Zhenqi¹²,Song Hualong³^ORCID,Scott Peter³^ORCID,Du Xiubo⁴,Ren Jinsong¹²^ORCID,Qu Xiaogang¹²^ORCID

Affiliation:

1. Laboratory of Chemical Biology, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China

2. University of Science and Technology of China, Hefei, Anhui 230029, China

3. Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK

4. College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, P. R. China

Abstract

Chiral metallohelix ΛA inhibited amyloid-β aggregation with enantioselectivity in vivo. Beyond the intrinsic bioactivity, alkyne-bearing ΛA was employed as a building block for convenient visualization and versatile modification via click reaction.

Funder

Chinese Academy of Sciences

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC05897A

Reference60 articles.

1. 2022 Alzheimer's disease facts and figures