Host–guest complexation of APP<sup>+</sup> with cucurbit[7]uril. Theoretical and experimental studies on the supramolecular inhibition of its cytotoxicity on SERT-Reference-Cited by-同舟云学术

Host–guest complexation of APP⁺ with cucurbit[7]uril. Theoretical and experimental studies on the supramolecular inhibition of its cytotoxicity on SERT

Published:2022 Issue:32 Volume:46 Page:15732-15739
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Almendras Sebastián¹,Zárate Ana María¹,Dinamarca-Villarroel Luis¹,Guerra Daniel²,Fuentealba Denis²^ORCID,Eltit Jose M.³,Aliaga Margarita E.²^ORCID,Fierro Angélica¹,Pérez Edwin G.¹^ORCID

Affiliation:

1. Department of Organic Chemistry, School of Chemistry, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile

2. Department of Physical Chemistry, School of Chemistry, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile

3. Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA

Abstract

The supramolecular binding behavior of APP+ and CB[7] in aqueous solution was studied by different techniques. APP+ showed cytotoxicity towards HEK293 cells expressing hSERT. This cytotoxicity was inhibited by the treatment of the cells with CB[7].

Funder

Fondo Nacional de Desarrollo Científico y Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ01963A

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5. N-Alkylated Analogs of 4-Methylamphetamine (4-MA) Differentially Affect Monoamine Transporters and Abuse Liability

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