Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives-Reference-Cited by-同舟云学术

Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives

Published:2022 Issue:9 Volume:39 Page:1856-1875
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Shen Siyu¹²,Tong Yuru³,Luo Yunfeng¹,Huang Luqi⁴,Gao Wei¹²^ORCID

Affiliation:

1. School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China

2. Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China

3. School of Pharmaceutical Sciences, Capital Medical University, Beijing, 100069, China

4. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences, Beijing 100700, China

Abstract

This paper mainly focused on the asymmetric synthesis of natural product PTOX by biosynthesis and total synthesis, and pharmacological activities of its derivatives.

Funder

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NP/D2NP00028H

Reference148 articles.

1. Etoposide (VP-16-213)

2. Preliminary Evaluation of VM-26 A New Epipodophyllotoxin Derivative, in the Treatment of Urogenital Tumours

3. Clinical and pharmacokinetic study of oral NK611, a new podophyllotoxin derivative

4. Bcl-2 prevents topoisomerase II inhibitor GL331-induced apoptosis is mediated by down-regulation of poly(ADP-ribose)polymerase activity

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