A HPLC-SRM-MS based method for the detection and quantification of methotrexate in urine at doses used in clinical practice for patients with rheumatological disease: a potential measure of adherence-Reference-Cited by-同舟云学术

A HPLC-SRM-MS based method for the detection and quantification of methotrexate in urine at doses used in clinical practice for patients with rheumatological disease: a potential measure of adherence

Published:2015 Issue:6 Volume:140 Page:1981-1987
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Bluett J.¹²³⁴⁵,Riba-Garcia I.⁶⁷⁸⁴⁵,Hollywood K.⁶⁷⁸⁴⁵,Verstappen S. M. M.⁹¹⁰³⁴⁵,Barton A.¹²³⁴⁵,Unwin R. D.⁶⁷⁸⁴⁵

Affiliation:

1. Arthritis Research UK Centre for Genetics and Genomics

2. Institute of Inflammation and Repair

3. The University of Manchester

4. Manchester

5. UK

6. Centre for Advanced Discovery and Experimental Therapeutics (CADET)

7. Central Manchester University Hospitals NHS Foundation Trust

8. Manchester Academic Health Sciences Centre

9. Arthritis Research UK Centre for Epidemiology

10. Centre for Musculoskeletal Research

Abstract

A novel assay to measure adherence to low-dose oral methotrexate.

Funder

Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/AN/C4AN02321H

Reference24 articles.

1. The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century

2. Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA Study

3. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update

4. Adherence to disease-modifying antirheumatic drugs and the effects of exposure misclassification on the risk of hospital admission

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