Magnetic nanoparticle-infiltrated hydroxyapatite scaffolds accelerate osteoclast apoptosis by inhibiting autophagy-aggravated ER stress-Reference-Cited by-同舟云学术

Magnetic nanoparticle-infiltrated hydroxyapatite scaffolds accelerate osteoclast apoptosis by inhibiting autophagy-aggravated ER stress

Published:2022 Issue:40 Volume:10 Page:8244-8257
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Zhu Yue¹²,Li Zhiyu³,Sun Xiaoqing³,Gao Yichun³,Kang Ke³,He Jing³^ORCID,Wu Yao³^ORCID

Affiliation:

1. College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Huaxi University Town, Dongqing South Road, Guiyang 550025, Guizhou, China

2. Nano-drug Technology Research Center at Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China

3. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610064, P. R. China

Abstract

Magnetic hydroxyapatite scaffold promoted osteoclast apoptosis and decreased osteoclast proliferation. Suitable magnetic microenvironments increased adequate ATP supply and decreased ROS, which resulted in inhibiting autophagy-aggravated ER stress.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D2TB01392D

Reference43 articles.

1. Intramembranous ossification and endochondral ossification are impaired differently between glucocorticoid-induced osteoporosis and estrogen deficiency-induced osteoporosis

2. Modulated podosome patterning in osteoclasts by fullerenol nanoparticles disturbs the bone resorption for osteoporosis treatment

3. Mn-containing bioceramics inhibit osteoclastogenesis and promote osteoporotic bone regeneration via scavenging ROS

4. The effect of magnetic therapy and moderate aerobic exercise on osteoporotic patients

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