Rhenium(i) complexation–dissociation strategy for synthesising fluorine-18 labelled pyridine bidentate radiotracers

Author:

Klenner Mitchell A.12345ORCID,Zhang Bo6783ORCID,Ciancaleoni Gianluca9101112ORCID,Howard James K.123ORCID,Maynard-Casely Helen E.123ORCID,Clegg Jack K.1314153ORCID,Massi Massimiliano45163ORCID,Fraser Benjamin H.123ORCID,Pascali Giancarlo1231718ORCID

Affiliation:

1. Human Health & National Deuteration Facility

2. Australian Nuclear Science and Technology Organisation (ANSTO)

3. Australia

4. School of Molecular and Life Sciences

5. Curtin University

6. School of Chemistry

7. Monash University

8. Melbourne

9. Dipartmento di Chimica e Chimica Industriale

10. Universit à di Pisa

11. Pisa

12. Italy

13. School of Chemistry and Molecular Biosciences

14. The University of Queensland

15. St. Lucia

16. Bentley

17. Brain and Mind Centre

18. The University of Sydney

Abstract

A novel fluorine-18 radiolabelling method employing rhenium(i) mediation is described herein. In less than 1 minute, fluorine-18 labelled complexes and ligands were synthesised in greater than 80% and 60% radiochemical yields (RCY), respectively.

Funder

Australian Institute of Nuclear Science and Engineering

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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