Selective synthesis of N-protected exo-spiro[oxirane-3,2′-tropanes]-Reference-Cited by-同舟云学术

Selective synthesis of N-protected exo-spiro[oxirane-3,2′-tropanes]

Published:2019 Issue:10 Volume:6 Page:1692-1697
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Mandzhulo Aleksandr¹²³⁴⁵,Vashchenko Iryna¹²³,Gerasov Andrii¹²³,Vovk Mykhaylo⁴⁵²³,Rusanov Eduard⁴⁵²³,Fetyukhin Volodymyr¹²³,Lukin Oleg¹²³,Shivanyuk Alexander¹²³⁶⁷^ORCID

Affiliation:

1. Life Chemicals Inc.

2. Kyiv

3. Ukraine

4. Institute of Organic Chemistry

5. National Academy of Sciences of Ukraine

6. The Institute of High Technologies

7. Taras Shevchenko National University of Kyiv

Abstract

N-Cbz- and N-Boc-protected exo-spiro[oxirane-3,2′-tropanes] were selectively synthesized via either epoxidation or hydroxybromination/dehydrobromination of the corresponding alkenes.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QO/C9QO00377K

Reference22 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. Total synthesis of scopine, pseudoscopine, and nor- derivatives

3. Stereocontrolled epoxidations of cycloheptene derivatives in the palladium-catalyzed route to tropane alkaloids. Total syntheses of scopine and pseudoscopine

4. Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions

5. Anti-cholinergics mecamylamine and scopolamine alleviate motion sickness-induced gastrointestinal symptoms through both peripheral and central actions

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