Synthesis of defined mono-de-N-acetylated β-(1→6)-N-acetyl-d-glucosamine oligosaccharides to characterize PgaB hydrolase activity-Reference-Cited by-同舟云学术

Synthesis of defined mono-de-N-acetylated β-(1→6)-N-acetyl-d-glucosamine oligosaccharides to characterize PgaB hydrolase activity

Published:2019 Issue:43 Volume:17 Page:9456-9466
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Forman Adam¹²³⁴^ORCID,Pfoh Roland⁵⁶³⁷^ORCID,Eddenden Alexander¹²³⁴,Howell P. Lynne⁵⁶³⁷⁸^ORCID,Nitz Mark¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Toronto

3. Toronto

4. Canada M5S 3H6

5. Program in Molecular Medicine

6. The Hospital for Sick Children

7. Canada M5G 0A4

8. Department of Biochemistry

Abstract

Mono-de-N-acetylated β-(1→6)-N-acetyl-d-glucosamine penta- and hepta-saccharides were obtained using a convergent synthesis. The site of de-N-acetylation drives the selectivity of hydrolysis by PgaB.

Funder

Canadian Institutes of Health Research

Canadian Glycomics Network

Canada Research Chairs

Canada Foundation for Innovation

Ontario Research Foundation

Institute of Infection and Immunity

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB02079A

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